Involvement of NMDA and AMPA receptors in the antidepressant-like activity of antidepressant drugs in the forced swim test
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منابع مشابه
Involvement of NMDA and AMPA receptors in the antidepressant-like activity of antidepressant drugs in the forced swim test.
BACKGROUND The involvement of glutamate system (particularly the NMDA and AMPA receptors) in the mechanism of antidepressant activity was demonstrated in preclinical and clinical studies. METHODS In the present study, we investigated the effect of NMDA and AMPA receptors' ligands (agonists and antagonists) on the antidepressant-like activity of escitalopram, milnacipran, imipramine and reboxe...
متن کاملShort communication Involvement of NMDA and AMPA receptors in the antidepressant-like activity of antidepressant drugs in the forced swim test
Background: The involvement of glutamate system (particularly the NMDA and AMPA receptors) in the mechanism of antidepressant activity was demonstrated in preclinical and clinical studies. Methods: In the present study, we investigated the effect of NMDA and AMPA receptors’ ligands (agonists and antagonists) on the antidepressant-like activity of escitalopram, milnacipran, imipramine and reboxe...
متن کاملNMDA and AMPA receptors are involved in the antidepressant-like activity of tianeptine in the forced swim test in mice.
It is known that tianeptine exhibits antidepressant-like activity. Its influence on the glutamatergic system is also known, but the mechanisms involved in this activity remain to be established. The aim of this study was to investigate the involvement of the glutamate pathway in the antidepressant-like action of tianeptine. We investigated the effects of N-methyl-D-aspartate (NMDA) and α-amino-...
متن کاملNMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in mice.
Several lines of evidence suggest an antidepressant-like activity for 3-[(methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MTEP), a highly selective, non-competitive antagonist of metabotropic glutamate receptors subtype 5 (mGluR(5)). This effect has been observed following both acute and chronic MTEP treatments in behavioral tests and experimental models of depression, such as the forced swim test (...
متن کاملThe antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors.
The effect of inositol as an antidepressant was previously demonstrated in both animal models of depression-like behavior and in clinical trials. Unlike most antidepressant drugs, inositol does not have a clear target in the synapse and was not demonstrated to alter monoamine levels in the brain. The present study attempted to draw a psychopharmacological profile of inositol's behavioral effect...
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ژورنال
عنوان ژورنال: Pharmacological Reports
سال: 2013
ISSN: 1734-1140
DOI: 10.1016/s1734-1140(13)71080-6